VivoQuant^TM: Pre-clinical Image Postprocessing

VivoQuant^TM is inviCRO's multi-modality post-processing suite for SPECT, CT, PET, MR and optical imaging data. DICOM, NifTI, and raw data can be imported as well as many proprietary formats from pre-clinical imaging equipment. VivoQuant combines fundamental viewing functionality with powerful tools for fine-tuning images, isolating and analyzing regions of interest, and more. Multiple display modes including orthogonal views, slice views, special co-registration multi-views as well as 3D MIP and volume renderings allow users to optimally view information of interest. Built-in tools allow the imaging scientist to extract the information she or he needs with minimal effort.
Please contact us at support@invicro.com for more details on how to trial VivoQuant.

VQ 1.20: The Third Dimension called - We responded!

In VQ 1.20, inviCRO has further enhanced the 3D ROI tool and its integration into inviCRO's other tools, such as the Advanced Brain Atlas Segmentation. Shown here are renderings of a rat brain atlas with additional nasal regions on the left, and the atlas after registration with an input CT dataset on the right.

2012-03-07 » News: VivoQuant export renderings to Browser

VivoQuant 1.21 now allows the export of ROI renderings to your favorite (non-IE) web browser. Thanks to the X Toolkit (XTK), sharing your ROI data has become even more simple. Now your audience does not need a VivoQuant license to be able to check out your latest ROIs or Atlas work.
The export is implemented as a VivoScript, using VivoQuant's brand new ScriptEngine, which means the exported web page can be customized very easily.
Currently, experience is best on Chrome and Firefox, however, also in Safari you can enable WebGL. Internet Explorer requires the installation of a plugin.
VivoQuant 1.21 will come with many more VivoScript examples, e.g. automatic segmentation, a humane rat skinner, export of new movie types, etc...

2011-11-11 » News: VivoQuant 1.20 released

inviCRO is excited to announce the release of VivoQuant 1.20. With new and expanded functionality, the development team has been hard at work to deliver an image viewing and analysis platform that is more powerful, flexible, efficient and easier to use for your research needs. VivoQuant users will be introduced to a further revamped and improved 3D ROI tool, Bruker and Aspect Imaging MR data loading support, PET/MR viewing support, scriptable workflows, expanded DICOM support, and much more!
inviCRO has recently signed non-exclusive distribution agreements with two leading manufacturers of pre-clinical MR systems for distribution of VivoQuant as their multi-modal solution for viewing and analyzing image data.

New Features

Overhauled 3D ROI tool with extended functionality, improved performance and increased integration with the iPACS and inviCRO’s plug-in segmentation modules
Drastic improvements for handling MR data including extended support for loading Bruker and Aspect Imaging MR image data as well as the ability to load anisotropic MR data as volume data for PET/MR and MR/Optical applications
Scriptable (xml) Workflows Tool for creating user-friendly "Follow-me" protocols
Histogram percentile calculator incorporated with the Min/Max tool
Preprocessing tool for advanced users to semi-automate their preprocessing routines
Ability to fuse 1-slice 2D optical data with n-slice planar data
And about 25 smaller improvements as well as over 50 bugfixes
Support for Anaglyph 3D images and movies. Order your own glasses today.

More examples (click on image to enlarge)


Example workflow, guiding users through complicated procedures	ROI Analysis of a SPECT/CT of a Squirrel Monkey with segmentations of brain, kidneys, bladder, heart... Please note, these images shows two different animals.	Co-registration of PET/MR data Bruker ICON 1T MR, GE Vista PET By courtesey of: U. Mahmood, P. Heidari and P. Habibollahi. MGH, Boston	Example 3D Anaglyph movie generated with VQ. Get your 3D glasses.

VivoQuant is available for Windows XP/Vista/7 (32/64 bit) as well as Mac OS X 10.6 (Snow Leopard) and 10.7 (Lion).
The brain and segmentation plugins of inviCRO have also been updated to make full use of VivoQuant's new and improved capabilities and additionally the integration into inviCRO's iPACS has been further enhanced.
For a full list of changes, please consult the ChangeLog.

2011-10-19 » News: First release candidate of VQ 1.20 available

The new VQ 1.20 has entered final testing and is now available for early adopters. With more than 70 improvements and fixes, including a fully overhauled and extended 3D ROI tool, VQ 1.20 is another major release.

2011-04-12 » News: New VivoQuant website launched

We have now launched a web-site dedicated to our post-processing software VivoQuant. From now on you will find here all news and new versions of VQ.

2011-04-10 » News: Release candidated for VQ 1.19 and 3D ROI Tool available

Please find installers of release candidates for Windows 32-bit and 64-bit as well as Mac OS X 64-bit in the Download section. These versions are currently undergoing last tests before the final release of the 1.19 stable version.

VQ 1.19: Welcome to the Third Dimension - The 3D ROI tool

Thanks to the new 3D ROI tool, VQ now allows to manually, semi- or fully automatically classify each individual pixel of a 3D volume or a series of 2D planar images, using powerful tools, such as the known spline tool and new ones such as the 3D and 2D paint brush.
Sophisticated constrained thresholding and region grow segmentation algorithms add the user to perform classifications efficiently and effectively.

2011-04-8 » News: VivoQuant 1.19: Welcome to the Third Dimension

inviCRO's latest VivoQuant features the powerful fully 3D ROI tool. For the first time, you will be able to classify each individual voxel of a three dimensional volume dataset. VQ will support your segmentation efforts with easy to use, however, powerful toolbox for manual, semi-automatic and fully automatic segmentation.
VQ continues to fully support multi-modal and dynamic data, also in the 3D ROI tool. You only have to do the segmentation for a fixed ROI once and it will be evaluated for all loaded datasets automatically.
Test versions of the new 3D ROI tool are available as part of our beta testing program (see left Download column).

Manual segmentation tools:

Painting Mode: Use a circle or 3D-sphere tool to classify voxels in one of the three orthogonal views.
Spline Tool: Use the spline tool to draw and manipulate ROI shapes, adjust the spline points, add/remove regions in free hand mode or use the thresholding tool and subsequently push ROI borders back in or expand them using the Bully.
Any ROI can easily be eroded or dilated to remove or add to the outer layer of voxels. This tools allows to clean-up images, as well as compensate for effects such as partial volume or limited resolution.

Semi-automatic segmentation tools:

The 3D ROI tool provides powerful thresholding methods:

Global threshold classifies all voxels within a given value range.
Connected thresholding allows to additionally set a seed point, from which all voxels in the given range are added to the ROI. Allows easy segmentation of lungs, of if constricted to a region of Xenograft tumors or other border regions.
Neighborhood thresholding also applies a connected thresholding, however, only adds voxels whose neighbors also fulfill the thresholding condition. This method can be used to efficiently segment separated compartments such as lungs or the brain.

Fully-automatic segmentation tools:

Histogram-based auto-thresholding allows to separate any input ROI into foreground and background, e.g. outside air and body of an animal, or if applied on the body it separates tissue from bone.
Confidence Connected auto-thresholding requires a seed point and evaluates the voxels in its neighborhood to then add all connected voxels within a certain variance- and mean-based confidence level.

inviCRO iPACS:

Full integration into inviCRO's iPACS Data Management System and the automated analysis tools, such as the tumor analysis and atlas-based brain tools. ROIs and quantification results can be stored and later retrieved to and from an iPACS with one click. Making it easier than ever before to exchange and archive (CFR21 part 11 compatible) your analysis results.

VivoQuantTM: Pre-clinical Image Postprocessing